TY - JOUR
AB - In the present study, the dietary effects of mead acid (MA; 5,8,11‑eicosatrienoic acid) on 7,12‑dimethylbenz[a]anthracene (DMBA)‑induced breast cancer in female Sprague‑Dawley rats were examined. The 2.4 and 4.8% MA diets were commenced when the rats were 6 weeks of age. DMBA was administered by a single oral ingestion when the rats were 7 weeks of age, and the rats were maintained on the respective diets until 19 weeks of age. Tumor weight, histopathology, cell kinetics, and the fatty acid composition in breast tissue and serum were examined. In the control (CTR) group, the DMBA‑exposed rats were fed a basal diet (0% MA). The results revealed that there were no significant differences in tumor incidence, cell kinetics and in the N‑6/N‑3 ratio in breast tissue between the groups. Only the N‑6/N‑3 ratio of fatty acid composition in serum was significantly decreased in the 2.4% MA diet group. In previous studies, the 2.4% MA diet was shown to suppress N‑methyl‑N‑nitrosourea‑induced luminal A mammary cancer by decreasing cancer cell proliferation. The findings of the present study differ from those of previous studies with different breast cancer models. To further clarify the effects of MA against breast carcinogenesis, further investigations with different experimental breast cancer models are recommended.
AD - Division of Central Laboratory of Medicine and Pathology, Wakayama Medical University Hospital, Wakayama 641‑8510, Japan
Department of Nutrition, Koshien University, Takarazuka, Hyogo 665‑0006, Japan
Ethics Review Center, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan
Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan
Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo 663‑8558, Japan
Department of Public Health, Faculty of Medicine, University of Toyama, Toyama 930‑0194, Japan
Department of Pathology, Osaka Prefectural Saiseikai Izuo Hospital, Osaka 551‑0032, Japan
AU - Kinoshita,Yuichi
AU - Yoshioka,Masahiro
AU - Emoto,Yuko
AU - Yuri,Takashi
AU - Yuki,Michiko
AU - Koyama,Chihiro
AU - Takenouchi,Akiko
AU - Hamazaki,Kei
AU - Tsubura,Airo
AU - Yoshizawa,Katsuhiko
DA - 2020/11/01
DO - 10.3892/ijfn.2020.7
IS - 2
JO - Int J Funct Nutr
KW - breast cancer
7
12‑dimethylbenz[a]anthracene
polyunsaturated fatty acid
mead acid
rat
PY - 2020
SN - 2634-7989
2634-7237
SP - 7
ST - Dietary effect of mead acid on DMBA‑induced breast cancer in female Sprague‑Dawley rats
T2 - International Journal of Functional Nutrition
TI - Dietary effect of mead acid on DMBA‑induced breast cancer in female Sprague‑Dawley rats
UR - https://doi.org/10.3892/ijfn.2020.7
VL - 1
ER -