TY - JOUR AB - Heparanase is an enzyme that degrades extracellular glycoprotein to release heparan sulfate molecules. CD44 variant exon 3 (CD44v3), a receptor for heparan sulfate, generates intracellular signals for cell migration. Production of CD44v3 and expression of heparanase were detected by immunohistochemistry and in situ hybridization, respectively. In 145 cases of colon cancer, heparanase mRNA and CD44v3 protein were detected in 46% and 43%, respectively. Co-expression of heparanase and CD44v3 was found in cases of 12% of Dukes' B, 32% of Dukes' C, and 57% of Dukes' D cases. Survival analysis found a significantly poorer prognosis in patients showing concurrent expression of heparanase and CD44v3 than in patients not showing both (p<0.0001). Concurrent expression of heparanase and CD44v3 might be a mechanism of cancer invasion and metastasis in colon cancer. AD - Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara 634-8521, Japan. cooninh@zb4.so-net.ne.jp null AU - Kuniyasu,Hiroki AU - Chihara,Yoshitomo AU - Kubozoe,Tadahiko AU - Takahashi,Tadateru DA - 2002/09/01 DO - 10.3892/ijmm.10.3.333 EP - 337 IS - 3 JO - Int J Mol Med PY - 2002 SN - 1107-3756 1791-244X SP - 333 ST - Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer T2 - International Journal of Molecular Medicine TI - Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer UR - https://doi.org/10.3892/ijmm.10.3.333 VL - 10 ER -