TY - JOUR AB - The receptor for advanced glycation end products (RAGE) is thought to play a critical role in diabetic atherosclerosis. Accordingly, a functional -374T/A polymorphism in RAGE gene promoter has been associated with macrovascular complications in type 1 diabetic patients. However, the extent to which this common variant influences the risk of coronary artery disease (CAD) in the general population remains to be determined. We genotyped the -374T/A RAGE polymorphism in 259 non-diabetic individuals, of whom 175 had angiographically documented coronary artery disease (CAD patients) and 84 had normal coronary angiography (CAD-free control subjects). Homozygosity for the -374A allele was found in 9.7% of the CAD patients versus 22.6% of the CAD-free subjects (p=0.005). By means of a multiple logistic regression analysis, the AA genotype of the -374T/A polymorphism was shown to be independently associated with a reduced risk of CAD (adjusted odds ratio 0.33, 95% CI 0.15 to 0.73; p=0.006). Our observations suggest that the -374T/A polymorphism of the RAGE gene may reduce susceptibility to CAD, thus exerting a protective effect on coronary risk. Future pathophysiological studies may be worthwhile to clarify the mechanisms behind this association. AD - Department of Cardiology, IRCCS San Matteo Hospital, University of Pavia, I-27100 Pavia, Italy. c.falcone@smatteo.pv.it null AU - Falcone,Colomba AU - Campo,Ilaria AU - Emanuele,Enzo AU - Buzzi,Maria,P. AU - Zorzetto,Michele AU - Sbarsi,Ilaria AU - Cuccia,Mariaclara DA - 2004/12/01 DO - 10.3892/ijmm.14.6.1061 EP - 1064 IS - 6 JO - Int J Mol Med PY - 2004 SN - 1107-3756 1791-244X SP - 1061 ST - Relationship between the -374T/A RAGE gene polymorphism and angiographic coronary artery disease T2 - International Journal of Molecular Medicine TI - Relationship between the -374T/A RAGE gene polymorphism and angiographic coronary artery disease UR - https://doi.org/10.3892/ijmm.14.6.1061 VL - 14 ER -