TY - JOUR AB - Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly understood, laboratory studies on cancer cell lines suggest that nucleotide excision repair (NER) is the main mechanism responsible for this resistance by increased platinum-DNA-adduct removal. NER pathway is a network of many proteins gathered in a DNA-repair system. The excision repair cross complementing-group 1 (ERCC1) gene has the leading role in NER-pathway because of its damage recognition and excision ability. In this report we reviewed the pathway leading to ERCC1 gene transcription and translation in cancer cells when exposed to cisplatin. We summarized data from different cancer cell lines and human cancers showing that the high level of ERCC1-mRNA and/or ERCC1 protein is associated with resistance to platinum compounds with direct impact on cancer patient survival and finally we analyzed drugs interfering with ERCC1 gene expression and causing the reversal of the platinum resistance when given to cancer cells prior to platinum-based chemotherapy. AD - Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506-2519, USA. raltaha@hsc.wvu.edu null AU - Altaha,Ramin AU - Liang,Xiaobing AU - Yu,Jing,Jie AU - Reed,Eddie DA - 2004/12/01 DO - 10.3892/ijmm.14.6.959 EP - 970 IS - 6 JO - Int J Mol Med PY - 2004 SN - 1107-3756 1791-244X SP - 959 ST - Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer T2 - International Journal of Molecular Medicine TI - Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer UR - https://doi.org/10.3892/ijmm.14.6.959 VL - 14 ER -