TY - JOUR AB - In order to investigate the clinical value of ATPase family AAA domain containing 3A (ATAD3A), a potential anti-apoptotic factor in prostate cancer (PCa), immunohistochemistry was used to measure ATAD3A expression in pathological specimens from 86 Chinese patients and in 183 tissue-array samples from American patients. The effect of ATAD3A on the expression of prostate specific antigen (PSA) and drug resistance in PCa cell lines was determined by in vitro experiments. ATAD3A was detected in 74 of 86 (86.0%) Chinese specimens and in 145 of 183 (79.2%) American patient samples. No difference was found in ATAD3A expression between these two patient groups. In vitro, silencing of ATAD3A expression reduced PSA secretion and cisplatin resistance, suggesting that ATAD3A was associated with PSA secretion and drug resistance in PCa. AD - Institute of Medicine, Chung-Shan Medical University, Taichung, Taiwan, R.O.C. Graduate Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan, R.O.C. null Institute of Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan, R.O.C. AU - Huang,Kuo-Hsuan AU - Chow,Kuan-Chih AU - Chang,Hui-Wen AU - Lin,Tze-Yi AU - Lee,Meng-Chih DA - 2011/07/01 DO - 10.3892/ijmm.2011.670 EP - 15 IS - 1 JO - Int J Mol Med KW - prostate cancer disease progression ATPase family AAA domain containing 3A drug resistance prostate specific antigen PY - 2011 SN - 1107-3756 1791-244X SP - 9 ST - ATPase family AAA domain containing 3A is an anti-apoptotic factor and a secretion regulator of PSA in prostate cancer T2 - International Journal of Molecular Medicine TI - ATPase family AAA domain containing 3A is an anti-apoptotic factor and a secretion regulator of PSA in prostate cancer UR - https://doi.org/10.3892/ijmm.2011.670 VL - 28 ER -