TY - JOUR AB - The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose of Trolox decreased phorbol 12-myristate 13-acetate (PMA)-induced invasion and migration of both A549 and HeLa cancer cells. We also found that Trolox suppressed both the expression and the proteolytic activity of matrix metalloproteinase-9 (MMP-9), and that the promoter activity of PMA-induced MMP-9 was inhibited by Trolox. Our results show that Trolox inhibits the transcriptional activity of MMP-9 by suppression of NF-κB transactivation. These results indicate that Trolox inhibits NF-κB-mediated MMP-9 expression, leading to the suppression of migration and invasion in lung and cervical cancer cells. Trolox is a potential agent for clinical use in preventing the invasion and metastasis of human malignant lung and cervical cancers. AD - Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Gyeonggi-do 461-713, Republic of Korea null School of Life Sciences and Biotechnology, Korea University, 5-1 Anam-dong, Seongbuk-gu, Seoul 136-701, Republic of Korea AU - Sung,Ho, Joong AU - Kim,Yoonseo AU - Kang,Hyereen AU - Sull,Jae ,Woong AU - Kim,Yoon ,Suk AU - Jang,Sung-Wuk AU - Ko,Jesang DA - 2012/02/01 DO - 10.3892/ijmm.2011.832 EP - 251 IS - 2 JO - Int J Mol Med KW - Trolox cell migration invasion matrix metallo­proteinase-9 lung cancer cervical cancer PY - 2012 SN - 1107-3756 1791-244X SP - 245 ST - Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells T2 - International Journal of Molecular Medicine TI - Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells UR - https://doi.org/10.3892/ijmm.2011.832 VL - 29 ER -