TY - JOUR AB - Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has been shown to act as a tumor suppressor whose function includes important roles in regulating oxidative stress, indicating a potential role in oxidative damage-associated cancer. Accumulating evidence has revealed that PTEN also acts as a pivotal determinant of cell fate, regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. Cells are continuously exposed to ROS, which represent mutagens and are thought to be a major contributor to cancer and the aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, PTEN and the roles of oxidative stress in phosphoinositide-3 kinase/AKT signaling are summarized with a focus on the links between the pathways and ROS in cancer and aging. AD - Department of Environmental Health Science, Nara Women's University, Nara 630-8506, Japan AU - Kitagishi,Yasuko AU - Matsuda,Satoru DA - 2013/03/01 DO - 10.3892/ijmm.2013.1235 EP - 515 IS - 3 JO - Int J Mol Med KW - PTEN PI3K AKT ROS PPAR WRN SIRT1 cell signaling PY - 2013 SN - 1107-3756 1791-244X SP - 511 ST - Redox regulation of tumor suppressor PTEN in cancer and aging (Review) T2 - International Journal of Molecular Medicine TI - Redox regulation of tumor suppressor PTEN in cancer and aging (Review) UR - https://doi.org/10.3892/ijmm.2013.1235 VL - 31 ER -