TY - JOUR AB - Glaucoma is the leading cause of irreversible blindness worldwide and there is no effective treatment thus far. The trabecular meshwork has been identified as the major pathological area involved. Certain signaling pathways in the trabecular meshwork, including the Wnt, lysophosphatidic acid and transforming growth factor‑β pathways, have been identified as novel therapeutic targets in glaucoma treatment. Meanwhile, it has been reported that key proteins in these pathways, particularly the primary transcription regulator Yes‑associated protein (YAP) and transcriptional co‑activator with PDZ‑binding motif (TAZ), exhibit interactions with the Hippo pathway. The Hippo pathway, which was first identified in Drosophila, has drawn great focus with regard to various aspects of studies in recent years. One role of the Hippo pathway in the regulation of organ size was indicated by more recent evidence. Defining the relevant physiological function of the Hippo pathway has proven to be extremely complicated. Studies have ascribed a role for the Hippo pathway in an overwhelming number of processes, including cell proliferation, cell death and cell differentiation. Therefore, the present review aimed to unravel the roles of YAP and TAZ in the Hippo pathway and the pathogenesis of glaucoma. Furthermore, a new and creative study for the treatment of glaucoma is provided. AD - Department of Biomedical Engineering, Medical School of University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China Institute of Organ Transplantation, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China 91388 Military Hospital, Zhanjiang, Guangdong 524022, P.R. China Department of Pediatrics, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China AU - Wang,Xin AU - Huai,Guoli AU - Wang,Hailian AU - Liu,Yuande AU - Qi,Ping AU - Shi,Wei AU - Peng,Jie AU - Yang,Hongji AU - Deng,Shaoping AU - Wang,Yi DA - 2018/03/01 DO - 10.3892/ijmm.2017.3352 EP - 1212 IS - 3 JO - Int J Mol Med KW - glaucoma Hippo Yes‑associated protein transcriptional co‑activator with PDZ‑binding motif Wnt lysophosphatidic acid transforming growth factor‑β PY - 2018 SN - 1107-3756 1791-244X SP - 1201 ST - Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review) T2 - International Journal of Molecular Medicine TI - Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review) UR - https://doi.org/10.3892/ijmm.2017.3352 VL - 41 ER -