TY - JOUR AB - Passiflora foetida L. (Passifloraceae), a perennial climber in general, is used for treating many ailments in conventional medicine. In this study, the anti-inflammatory effect of methanolic extracts of P. foetida L. (PFME) and the involvement of nuclear factor-κB (NF-κB) signalling in the regulation of inflammation were investigated. PFME prevented the production of prostaglandin E2 (PGE2) and the expression of inducible cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced macrophage cells. Additionally, PFME reduced the release of pro-inflammatory cytokines. Moreover, in LPS-induced RAW264.7 cells, the phosphorylation of MAPKs (ERK1/2, p38 and JNK) was suppressed by PFME. Furthermore, PFME inhibited the NF-κB activation induced by LPS, which was associated with nuclear p65 levels with the abrogation of IκBα degradation and subsequent decreases. These results indicated that the PFME inhibited the LPS-induced inflammatory and oxidative responses. Therefore, we propose that the PFME may be therapeutic for treating inflammatory diseases. AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Yuseong-gu, Daejeon 34141, Republic of Korea Center for Pharmaceutical and Medical Technology, The Agency for the Assessment and Application of Technology (BPPT), Kawasan Puspiptek Serpong, Tangerang, Banten 15314, Indonesia AU - Park,Ji-Won AU - Kwon,Ok-Kyoung AU - Ryu,Hyung ,Won AU - Paik,Jin-Hyub AU - Paryanto,Imam AU - Yuniato,Prasetyawan AU - Choi,Sangho AU - Oh,Sei-Ryang AU - Ahn,Kyung-Seop DA - 2018/06/01 DO - 10.3892/ijmm.2018.3559 EP - 3716 IS - 6 JO - Int J Mol Med KW - Passiflora foetida L. inflammation lipopolysaccharide MAPK nuclear factor-κB PY - 2018 SN - 1107-3756 1791-244X SP - 3709 ST - Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages T2 - International Journal of Molecular Medicine TI - Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages UR - https://doi.org/10.3892/ijmm.2018.3559 VL - 41 ER -