TY - JOUR AB - Sirtuin (SIRT)1, a member of the SIRT family, is a highly conserved NAD+‑dependent histone deacetylase, which has a regulatory role in numerous physiological and pathological processes by removing acetyl groups from various proteins. SIRT1 controls the activity of numerous transcription factors and cofactors, which impacts the downstream gene expression, and eventually alleviates oxidative stress and associated damage. Numerous studies have revealed that dysfunction of SIRT1 is linked with ocular diseases, including cataract, age‑associated macular degeneration, diabetic retinopathy and glaucoma, while ectopic upregulation of SIRT1 protects against various ocular diseases. In the present review, the significant role of SIRT1 and the potential therapeutic value of modulating SIRT1 expression in ocular development and eye diseases is summarized. AD - Department of Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China AU - Zhou,Mengwen AU - Luo,Jing AU - Zhang,Huiming DA - 2018/08/01 DO - 10.3892/ijmm.2018.3623 EP - 20 IS - 1 JO - Int J Mol Med KW - sirtuin 1 eye disease deacetylation resveratrol degeneration angiogenesis PY - 2018 SN - 1107-3756 1791-244X SP - 13 ST - Role of Sirtuin 1 in the pathogenesis of ocular disease (Review) T2 - International Journal of Molecular Medicine TI - Role of Sirtuin 1 in the pathogenesis of ocular disease (Review) UR - https://doi.org/10.3892/ijmm.2018.3623 VL - 42 ER -