TY - JOUR AB - In the present study, proteins differentially expressed between gastric cancer tissue and para‑tumoral normal gastric tissues were screened, and the function of the highly expressed protein C1QTNF6 in gastric carcinoma was investigated. The differential expression of mRNAs extracted from the tumor and adjacent tissues was analyzed using GeneChip assay. An AGS si‑C1QTNF6 cell line was constructed using shRNA‑C1QTNF6 lentivirus. The cell invasion and migration ability of C1QTNF6‑knockdown cells were determined by Transwell chamber migration and wound healing assays, respectively. The effects of C1QTNF6 on AGS cell cycle distribution and apoptosis were detected using a FACScan flow cytometer. The results demonstrated that the expression of 109 genes was increased and the expression of 129 was decreased in tumor tissues. Among these genes, the C1QTNF6 gene was highly expressed in tumor tissues and the AGS7901 cell line. C1QTNF6‑knockdown decreased the cell growth, and the proliferative and migration ability, as well as increasing the apoptosis of gastric carcinoma cells. In addition, the number of AGS cells in the G2/M phase was significantly increased after 5 days of C1QTNF6‑shRNA lentivirus infection. The results of the present study indicated that C1QTNF6 serves an important role in the development of gastric carcinoma. C1QTNF6 is involved in promoting the proliferation and migration, and in reducing the apoptosis of gastric carcinoma cells. These results provided a potential therapeutic target for the treatment of gastric carcinoma. AD - Department of Gastroenterology, Qingdao University Affiliated Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China Digestive Endoscopy Center, Department of Gastroenterology, Changhai Hospital, Shanghai 200433, P.R. China AU - Qu,Hai‑Xia AU - Cui,Lin AU - Meng,Xin‑Ying AU - Wang,Zhi‑Jie AU - Cui,Yan‑Xin AU - Yu,Yun‑Peng AU - Wang,Dong AU - Jiang,Xiang‑Jun DA - 2019/01/01 DO - 10.3892/ijmm.2018.3978 EP - 629 IS - 1 JO - Int J Mol Med KW - C1QTNF6 AGS7901 cell line gastric carcinoma PY - 2019 SN - 1107-3756 1791-244X SP - 621 ST - C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells T2 - International Journal of Molecular Medicine TI - C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells UR - https://doi.org/10.3892/ijmm.2018.3978 VL - 43 ER -