TY - JOUR AB - The outbreak of the 2019 coronavirus disease (named, COVID‑19), caused by the novel SARS‑CoV‑2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS‑CoV‑2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID‑19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID‑19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS‑CoV‑2 infection may further improve our understanding of COVID‑19 pathogenesis and suggest better therapeutic strategies. AD - Department of Biomedical and Biotechnological Sciences, University of Catania, I‑95123 Catania, Italy IRCCS (Scientific Institute for Research, Hospitalization and Healthcare) Centro Neurolesi ‘Bonino‑Pulejo’, I‑98124 Messina, Italy Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center (Affiliated to Tel‑Aviv University), Tel-Hashomer 5265601, Israel AU - Cavalli,Eugenio AU - Petralia,Maria,Cristina AU - Basile,Maria,Sofia AU - Bramanti,Alessia AU - Bramanti,Placido AU - Nicoletti,Ferdinando AU - Spandidos,Demetrios,A. AU - Shoenfeld,Yehuda AU - Fagone,Paolo DA - 2020/10/01 DO - 10.3892/ijmm.2020.4702 EP - 1273 IS - 4 JO - Int J Mol Med KW - COVID‑19 SARS‑CoV‑2 immune response bioinformatics PY - 2020 SN - 1107-3756 1791-244X SP - 1266 ST - Transcriptomic analysis of COVID‑19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection T2 - International Journal of Molecular Medicine TI - Transcriptomic analysis of COVID‑19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection UR - https://doi.org/10.3892/ijmm.2020.4702 VL - 46 ER -