TY - JOUR AB - Recently, the increasing emergency of traffic accidents and the unsatisfactory outcome of surgical intervention are driving research to seek a novel technology to repair traumatic soft tissue injury. From this perspective, decellularized matrix grafts (ECM‑G) including natural ECM materials, and their prepared hydrogels and bioscaffolds, have emerged as possible alternatives for tissue engineering and regenerative medicine. Over the past decades, several physical and chemical decellularization methods have been used extensively to deal with different tissues/organs in an attempt to carefully remove cellular antigens while maintaining the non‑immunogenic ECM components. It is anticipated that when the decellularized biomaterials are seeded with cells in vitro or incorporated into irregularly shaped defects in vivo, they can provide the appropriate biomechanical and biochemical conditions for directing cell behavior and tissue remodeling. The aim of this review is to first summarize the characteristics of ECM‑G and describe their major decellularization methods from different sources, followed by analysis of how the bioactive factors and undesired residual cellular compositions influence the biologic function and host tissue response following implantation. Lastly, we also provide an overview of the in vivo application of ECM‑G in facilitating tissue repair and remodeling. AD - Science and Education Management Center, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, P.R. China AU - Jiang,Yongsheng AU - Li,Rui AU - Han,Chunchan AU - Huang,Lijiang DA - 2021/02/01 DO - 10.3892/ijmm.2020.4818 EP - 474 IS - 2 JO - Int J Mol Med KW - extracellular matrix grafts decellularization protocols tissue engineering the host response PY - 2021 SN - 1107-3756 1791-244X SP - 463 ST - Extracellular matrix grafts: From preparation to application (Review) T2 - International Journal of Molecular Medicine TI - Extracellular matrix grafts: From preparation to application (Review) UR - https://doi.org/10.3892/ijmm.2020.4818 VL - 47 ER -