TY - JOUR AB - Insulin resistance (IR) is defined as impaired insulin function, reduced glucose uptake and increased glucose production, which can result in type II diabetes, metabolic syndrome and even bone metabolic disorders. A possible reason for the increasing incidence of IR is population aging. Adipose tissue (AT) is an important endocrine organ that serves a crucial role in whole‑body energy homeostasis. AT can be divided into white AT (WAT), beige AT and brown AT (BAT). Several mechanisms have been previously associated with age‑dependent IR in WAT. However, BAT, a metabolically active tissue, controls the levels of plasma glucose and triglyceride metabolism. Therefore, the present review aimed to summarize the mechanisms of age‑dependent IR induced by AT and to determine the role of WAT browning in achieving positive therapeutic outcomes in age‑dependent IR. AD - Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, P.R. China AU - Wu,Chuanlong AU - Yu,Pei AU - Sun,Ruixin DA - 2021/05/01 DO - 10.3892/ijmm.2021.4904 IS - 5 JO - Int J Mol Med KW - insulin resistance aging white adipose tissue brown adipose tissue type II diabetes PY - 2021 SN - 1107-3756 1791-244X SP - 71 ST - Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review) T2 - International Journal of Molecular Medicine TI - Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review) UR - https://doi.org/10.3892/ijmm.2021.4904 VL - 47 ER -