TY - JOUR AB - Generalized pustular psoriasis (GPP) is a rare and severe auto‑inflammatory skin disease that is characterized by recurrent, acute onset, and generalized pustular eruptions on erythematous, inflamed skin. GPP is traditionally classified as a variant of psoriasis vulgaris, even though recent clinical, histological and genetic evidence suggests that it is a heterogeneous disease and requires a separate diagnosis. In recent years, variants of IL36RN, CARD14, AP1S3 and MPO genes have been identified as causative or contributing to genetic defects in a proportion of patients affected by GPP. These disease‑related genes are involved in common inflammatory pathways, in particular in the IL‑1/IL‑36‑chemokines‑neutrophil pathogenic axis. At present, no standard therapeutic guidelines have been established for GPP management, and there is a profound need for novel efficacious treatments of GPP. Among them, biological agents antagonizing the IL‑36 pathway are promising therapeutics. The aim of the present review is to provide the most recent updates on the genetics, genotype‑phenotype correlation and pathological basis of GPP, as well as on biologic treatments available for GPP and relative clinical courses. AD - Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China AU - Zhou,Jiahong AU - Luo,Qing AU - Cheng,Yang AU - Wen,Xia AU - Liu,Jinbo DA - 2021/06/01 DO - 10.3892/ijmm.2021.4951 IS - 6 JO - Int J Mol Med KW - generalized pustular psoriasis mutation IL36RN gene CARD14 gene AP1S3 gene MPO gene pathoimmunology biologics treatment heterogeneity PY - 2021 SN - 1107-3756 1791-244X SP - 118 ST - An update on genetic basis of generalized pustular psoriasis (Review) T2 - International Journal of Molecular Medicine TI - An update on genetic basis of generalized pustular psoriasis (Review) UR - https://doi.org/10.3892/ijmm.2021.4951 VL - 47 ER -