TY - JOUR AB - As a major proton‑gated cation channel, acid‑sensitive ion channels (ASICs) can perceive large extracellular pH changes. ASICs play an important role in the occurrence and development of diseases of various organs and tissues including in the heart, brain, and gastrointestinal tract, as well as in tumor proliferation, invasion, and metastasis in acidosis and regulation of an acidic microenvironment. The permeability of ASICs to sodium and calcium ions is the basis of their physiological and pathological roles in the body. This review summarizes the physiological and pathological mechanisms of ASICs in digestive system diseases, which plays an important role in the early diagnosis, treatment, and prognosis of digestive system diseases related to ASIC expression. AD - Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China AU - Zhang,Li AU - Zheng,Liming AU - Yang,Xingyue AU - Yao,Shun AU - Wang,Hui AU - An,Jiaxing AU - Jin,Hai AU - Wen,Guorong AU - Tuo,Biguang DA - 2022/07/01 DO - 10.3892/ijmm.2022.5150 IS - 1 JO - Int J Mol Med KW - acid‑sensitive ion channels acidic microenvironment acidosis digestive system digestive system diseases PY - 2022 SN - 1107-3756 1791-244X SP - 94 ST - Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review) T2 - International Journal of Molecular Medicine TI - Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review) UR - https://doi.org/10.3892/ijmm.2022.5150 VL - 50 ER -