TY - JOUR AB - Non‑alcoholic fatty liver disease (NAFLD) is a clinically progressive illness that can advance from simple fatty liver to non-alcoholic hepatitis and liver fibrosis. Cirrhosis and hepatocellular carcinoma are two of the most common diseases caused by NAFLD. As there are no early disease biomarkers and no US Food and Drug Administration‑approved medications, treatment for NAFLD is still focused on altering lifestyle and dietary habits, which makes it difficult to treat effectively. As a result, a novel treatment is urgently needed to prevent NAFLD progression. Calcium (Ca2+) channels regulate intracellular Ca2+ homeostasis via the mediation of Ca2+ flow. Previous studies have reported that Ca2+ channel expression varies throughout the development and progression of NAFLD, which results in the dysregulation of intracellular Ca2+ homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction and autophagy suppression, all of which contribute to NAFLD progression. Several types of Ca2+ channels (including two‑pore segment channel 2, transient receptor potential, inositol triphosphate receptor, voltage‑dependent anion channel 1, store‑operated Ca2+ entry, purinergic receptor X7 and potassium Ca2+‑activated channel subfamily N member 4) have been identified as potential targets for preventing NAFLD development and controlling intracellular Ca2+ homeostasis. To achieve this, these channels can be blocked or activated, which exerts anti‑steatotic, anti‑inflammatory, anti‑fibrotic and other effects, which ultimately prevents the development of NAFLD. In the present review NAFLD therapeutics and the treatments that target Ca2+ channels that are currently being developed were examined. AD - Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China AU - Chen,Xingyue AU - Zhang,Li AU - Zheng,Liming AU - Tuo,Biguang DA - 2022/09/01 DO - 10.3892/ijmm.2022.5169 IS - 3 JO - Int J Mol Med KW - non‑alcoholic fatty liver disease calcium channels endoplasmic reticulum stress mitochondrial dysfunction therapeutic strategies PY - 2022 SN - 1107-3756 1791-244X SP - 113 ST - Role of Ca2+ channels in non-alcoholic fatty liver disease and their implications for therapeutic strategies (Review) T2 - International Journal of Molecular Medicine TI - Role of Ca2+ channels in non-alcoholic fatty liver disease and their implications for therapeutic strategies (Review) UR - https://doi.org/10.3892/ijmm.2022.5169 VL - 50 ER -