TY - JOUR AB - NM-3 is a prototype of chimeric virus between simian and human immunodeficiency viruses (SHIV). It grows in monkey lymphocytic cells in vitro and in vivo as well as in human cells. A mutant designated NM3-E65, which lacks expression of the entire vpu gene, was constructed from NM-3, and monitored for its replication property. Examination of growth properties in simian and human cells of SHIV, HIV, and their vpu mutants revealed that the vpu gene in the genome of the chimeric virus is functional, but non-essential for virus replication. AD - Department of Virology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan null AU - Adachi,Akio AU - Miyaura,Maki AU - Sakurai,Akiko AU - Yoshida,Akiko AU - Koyama,A.,Hajime AU - Fujita,Mikako DA - 2001/12/01 DO - 10.3892/ijmm.8.6.641 EP - 644 IS - 6 JO - Int J Mol Med PY - 2001 SN - 1107-3756 1791-244X SP - 641 ST - Growth characteristics of SHIV without the vpu gene T2 - International Journal of Molecular Medicine TI - Growth characteristics of SHIV without the vpu gene UR - https://doi.org/10.3892/ijmm.8.6.641 VL - 8 ER -