TY - JOUR AB - Curcumin, a component of turmeric (Curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. We examined the inhibitory effects of chemically synthesized derivatives of curcumin against inflammatory responses and compared them with those of curcumin, in order to find derivatives with stronger effects than curcumin. In a cell culture system using the mouse macrophage cell line RAW264.7, monoacetylcurcumin strongly inhibited IκB phosphorylation, nuclear factor (NF)-κB activation and tumor necrosis factor (TNF)-α production induced by lipopolysaccharide (LPS). In addition, oral administration of monoacetylcurcumin to mice led to greater suppression of TNF-α production after LPS stimulation than the administration of curcumin or tetrahydrocurcumin in vivo. Monoacetylcurcumin also inhibited the LPS-induced NF-κB activation in the liver. Collectively, monoacetylcurcumin is a potential chemopreventive agent for treating inflammatory responses more effectively than curcumin. AD - Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Hyogo 650-0017, Japan null AU - Nishida,Masayuki AU - Nishiumi,Shin AU - Mizushina,Yoshiyuki AU - Fujishima,Yoshimi AU - Yamamoto,Koji AU - Masuda,Atsuhiro AU - Mizuno,Shigeto AU - Fujita,Tsuyoshi AU - Morita,Yoshinori AU - Kutsumi,Hiromu AU - Yoshida,Hiromi AU - Azuma,Takeshi AU - Yoshida,Masaru DA - 2010/05/01 DO - 10.3892/ijmm_00000402 EP - 767 IS - 5 JO - Int J Mol Med PY - 2010 SN - 1107-3756 1791-244X SP - 761 ST - Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation T2 - International Journal of Molecular Medicine TI - Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation UR - https://doi.org/10.3892/ijmm_00000402 VL - 25 ER -