TY - JOUR AB - This study deals with the effects of daily inter-mittent fasting for 15 h upon the development of diabetes in sand rats exposed to a hypercaloric diet. The same pattern of daily intermittent fasting was imposed on sand rats maintained on a purely vegetal diet (control animals). Over the last 30 days of the present experiments, non-fasting animals gained weight, whilst intermittently fasting sand rats lost weight. In this respect, there was no significant difference between control animals and either diabetic or non-diabetic sand rats exposed to the hypercaloric diet. The postprandial glycemia remained fairly stable in the control animals. During a 3-week transition period from a purely vegetal to a hypercaloric diet, the post-prandial glycemia increased by 5.95±1.26 mM (n=6) in diabetic sand rats, as distinct from an increase of only 0.45±0.56 mM (n=6) in the non-diabetic animals. During the intermittent fasting period, the postprandial glycemia decreased significantly in the diabetic animals, but not so in the non-diabetic sand rats. Before the switch in food intake, the peak glycemia at the 30th min of an intraperitoneal glucose tolerance test was already higher in the diabetic than non-diabetic rats. In both the non-diabetic and diabetic sand rats, intermittent fasting prevented the progressive deterioration of glucose tolerance otherwise observed in non-fasting animals. These findings reveal that, at least in sand rats, intermittent daily fasting prevents the progressive deterioration of glucose tolerance otherwise taking place when these animals are exposed to a hypercaloric diet. AD - Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, Mostaganem, Algeria null AU - Belkacemi,Louiza AU - Selselet-Attou,Ghalem AU - Louchami,Karim AU - Sener,Abdullah AU - Malaisse,Willy,J. DA - 2010/11/01 DO - 10.3892/ijmm_00000523 EP - 765 IS - 5 JO - Int J Mol Med PY - 2010 SN - 1107-3756 1791-244X SP - 759 ST - Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations T2 - International Journal of Molecular Medicine TI - Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations UR - https://doi.org/10.3892/ijmm_00000523 VL - 26 ER -