TY - JOUR AB - Galectin-3 is a beta-galactoside-specific lectin that binds to laminin sugar-sites and is involved in tumor malignancy. Galectin-3 expression in relation to primary tumor and liver metastasis of colorectal cancer was examined to determined its involvement in cancer progression and metastasis. Immunohistochemical staining of galectin-3 was performed on 117 primary lesions and 15 liver metastases of colorectal cancer using TIB166 monoclonal antibody. The expression of galectin-3 was evaluated by grading the intensity of the staining as either negative, weakly positive, or strongly positive. Normal mucosa of all patients were strongly positive for galectin-3, but the staining in these tissues was still significantly less than in the primary lesions of the cancer (31.6%). Galectin-3 expression in the primary lesions was significantly increased, correlating with the progression of clinical stage (p=0. 0224), liver metastasis (p<0.0001), venous invasion (p=0.0048), and lymph node metastasis (p=0.0289). Liver metastatic lesions also showed up-regulated levels of galectin-3 compared to the primary lesions (p=0.0030). The group showing strongly positive galectin-3 had a significantly poorer prognosis than the negative/weakly positive group in terms of disease-free survival (p=0.0224). The strong expression of galectin-3 in colorectal cancer correlates with cancer progression, liver metastasis, and poor prognosis for patients. AD - The First Department of Surgery, Kinki University School of Medicine, Osakasayama, Osaka 589-8511, Japan. AU - Nakamura,M AU - Inufusa,H AU - Adachi,T AU - Aga,M AU - Kurimoto,M AU - Nakatani,Y AU - Wakano,T AU - Nakajima,A AU - Hida,J I AU - Miyake,M AU - Shindo,K AU - Yasutomi,M DA - 1999/07/01 DO - 10.3892/ijo.15.1.143 EP - 151 IS - 1 JO - Int J Oncol PY - 1999 SN - 1019-6439 1791-2423 SP - 143 ST - Involvement of galectin-3 expression in colorectal cancer progression and metastasis. T2 - International Journal of Oncology TI - Involvement of galectin-3 expression in colorectal cancer progression and metastasis. UR - https://doi.org/10.3892/ijo.15.1.143 VL - 15 ER -