TY - JOUR AB - We previously reported a functional interaction between aberrant Wnt signaling and Rac1/Rac1b GTPases in tumorigenesis. In this study, we further investigated the mechanistic role of nuclear Rac1b. Using chromatin immunoprecipitation (ChIP) studies, we show that Rac1b resides at the promoters of Wnt target genes, c-Myc and Cyclin D1, in HCT116 cells with aberrant Wnt pathway. In HEK293T cells with intact Wnt signaling, Rac1b is tethered to these same gene promoters independent of Wnt3A stimulation and is further observed to recruit Dishevelled and β-catenin in the absence of Wnt3A stimulation. Our studies suggest a novel transcriptional co-activator role of Rac1b in β-catenin/TCF-mediated transcription. AD - Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5T 3L9, Canada null Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada AU - Pethe,Vaijayanti ,V. AU - Charames,George ,S. AU - Bapat,Bharati DA - 2011/10/01 DO - 10.3892/ijo.2011.1066 EP - 810 IS - 4 JO - Int J Oncol KW - Rac1b Wnt signaling colon cancer PY - 2011 SN - 1019-6439 1791-2423 SP - 805 ST - Rac1b recruits Dishevelled and β-catenin to Wnt target gene promoters independent of Wnt3A stimulation T2 - International Journal of Oncology TI - Rac1b recruits Dishevelled and β-catenin to Wnt target gene promoters independent of Wnt3A stimulation UR - https://doi.org/10.3892/ijo.2011.1066 VL - 39 ER -