TY - JOUR AB - Chemopreventive effects of caffeine and curcumin were evaluated in the diethylnitrosamine (DEN)-induced hepatocarcinogenic rat model. Animals injected with DEN for 10 weeks (G2-10w) and 14 weeks (G2-14w) were hepato­carcinogenic rats. Animals injected with DEN and treated with curcumin and caffeine for 10 weeks (G3-10w, G4-10w) and 14 weeks (G3-14w, G4-14w) were compared with those in G2. Macroscopic and microscopic features suggested that treatment with caffeine, but not curcumin, for 10 and 14 weeks was effective in inhibiting DEN-induced hepatocarcinogenesis. Immunohistochemical and western blot analysis with proli­ferating cell nuclear antigen and glutathione S-transferase-P antibodies also showed that expression levels of these hepato­carcinogenic markers were more efficiently reduced by treatment with caffeine than curcumin. Our data demonstrate that caffeine could be a more potent compound than curcumin for prevention of hepatocarcinogenesis in DEN-induced rats. AD - Second Department of Internal Medicine, Tottori University School of Medicine, Tottori 683-8504, Japan AU - Fujise,Yuki AU - Okano,Jun-Ichi AU - Nagahara,Takakazu AU - Abe,Ryo AU - Imamoto,Ryu AU - Murawaki,Yoshikazu DA - 2012/06/01 DO - 10.3892/ijo.2012.1343 EP - 1788 IS - 6 JO - Int J Oncol KW - hepatocarcinogenesis diethylnitrosamine caffeine curcumin PY - 2012 SN - 1019-6439 1791-2423 SP - 1779 ST - Preventive effect of caffeine and curcumin on hepato­carcinogenesis in diethylnitrosamine-induced rats Corrigendum in /10.3892/ijo.2016.3577 T2 - International Journal of Oncology TI - Preventive effect of caffeine and curcumin on hepato­carcinogenesis in diethylnitrosamine-induced rats Corrigendum in /10.3892/ijo.2016.3577 UR - https://doi.org/10.3892/ijo.2012.1343 VL - 40 ER -