TY - JOUR AB - Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activities via its effect on a variety of biological pathways involved in cancer progression. In this study, we found that CAFs could induce prostate cancer cell EMT and invasion through a monoamine oxidase A (MAOA)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α) signaling pathway, which exploits reactive oxygen species (ROS) to drive a migratory and aggressive phenotype of prostate carcinoma cells. Moreover, CAFs was able to increase CXC chemokine receptor 4 (CXCR4) and interleukin-6 (IL-6) receptor expression in prostate cancer cells. However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1α signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer. AD - Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China Department of Urology, Tongji Medical College Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China AU - Du,Yuefeng AU - Long,Qingzhi AU - Zhang,Lin AU - Shi,Ying AU - Liu,Xioagang AU - Li,Xudong AU - Guan,Bin AU - Tian,Yanchao AU - Wang,Xinyang AU - Li,Lei AU - He,Dalin DA - 2015/12/01 DO - 10.3892/ijo.2015.3202 EP - 2072 IS - 6 JO - Int J Oncol KW - curcumin cancer-associated fibroblasts monoamine oxidase A/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling prostate cancer invasion PY - 2015 SN - 1019-6439 1791-2423 SP - 2064 ST - Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling T2 - International Journal of Oncology TI - Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling UR - https://doi.org/10.3892/ijo.2015.3202 VL - 47 ER -