TY - JOUR AB - The NAD-dependent protein deacetylase sirtuinĀ 3 (SIRT3) is an enzyme localized primarily in the mitochondrion, where it modulates cellular functions such as nutrient metabolism, ATP balance, antioxidant machinery, and other mechanisms fundamental to mitochondria. SIRT3 is closely associated with the pathogenesis of diverse disorders. In particular, it plays a dual role in the development and progression of cancer. In many cancers, SIRT3 acts as an oncogene by promoting or maintaining the malignant phenotypes of neoplastic cells, including uncontrolled proliferation, resistance to apoptosis, and increased motility or invasiveness; however, SIRT3 suppresses these phenotypes in certain types of malignancy. The underlying mechanisms involve depletion of intracellular reactive oxygen species, modulation of metabolic reprogramming, and regulation of intracellular signaling responsible for cell growth and death. This review summarizes recent findings concerning the characteristics and substrates/interacting partners of SIRT3, with particular emphasis on emerging mechanisms responsible for fine-tuning cellular behaviors that potentially underlie its conflicting roles in carcinogenesis. AD - Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China AU - Xiong,Yanlu AU - Wang,Mingxing AU - Zhao,Jinbo AU - Han,Yong AU - Jia,Lintao DA - 2016/12/01 DO - 10.3892/ijo.2016.3767 EP - 2235 IS - 6 JO - Int J Oncol KW - sirtuin 3 deacetylase cancer mechanism PY - 2016 SN - 1019-6439 1791-2423 SP - 2227 ST - Sirtuin 3: A Janus face in cancer (Review) T2 - International Journal of Oncology TI - Sirtuin 3: A Janus face in cancer (Review) UR - https://doi.org/10.3892/ijo.2016.3767 VL - 49 ER -