TY - JOUR AB - Glioblastoma is the most common brain cancer in adults. It represents one of the top ten malignant tumors with an average survival time of nine months despite treatments with surgery, radiotherapy and chemotherapy. Curcumin is a phytochemical turmeric isolated from root of the Curcuma longa plant. Accumulating evidence have proved that curcumin targets numerous cancer signaling pathways. The E3 ubiquitin ligase NEDD4, neural precursor cell expressed developmentally downregulated protein 4, is frequently overexpressed in various cancers. However, whether curcumin regulates NEDD4 expression has not been described in human cancers. Therefore, in this study, we explored the roles of NEDD4 in glioma cell proliferation, apoptosis and mobility. We further investigated whether curcumin exerts its antitumor activities via suppressing NEDD4 expression. We found that curcumin reduced the expression of NEDD4 and Notch1 and pAKT, leading to glioma cell growth inhibition, apoptosis, and suppression of migration and invasion. Moreover, deletion of NEDD4 expression enhanced the sensitivity of glioma cells to curcumin treatment. Thus, inactivation of NEDD4 by curcumin could be a promising approach for therapeutic intervention. AD - School of Life Science, Shandong University, Jinan, Shandong 250100, P.R. China Department of Neurosurgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, P.R. China AU - Wang,Xue AU - Deng,Jiaojiao AU - Yuan,Jinxia AU - Tang,Xin AU - Wang,Yuelong AU - Chen,Haifeng AU - Liu,Yi AU - Zhou,Liangxue DA - 2017/08/01 DO - 10.3892/ijo.2017.4037 EP - 477 IS - 2 JO - Int J Oncol KW - curcumin glioma NEDD4 invasion apoptosis proliferation PY - 2017 SN - 1019-6439 1791-2423 SP - 467 ST - Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells T2 - International Journal of Oncology TI - Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells UR - https://doi.org/10.3892/ijo.2017.4037 VL - 51 ER -