TY - JOUR AB - Extracellular vesicles (EVs), including micro‑vesicles and exosomes, are heterogeneous small membranous vesicles shed from the surface of myriad cells and are crucial in mediating intercellular communication. The vertical trafficking of cargo to the plasma membrane and subsequent redistribution of surface lipids may contribute to EV formation. Tumor‑derived extracellular vesicles (TD‑EVs) can carry complex, bioactive cargo, such as nucleic acids and proteins, during tumor metastasis. Paracrine information gets relayed by TD‑EVs to adjacent tumor cells and this allows a crosstalk between malignant cells. These structures may even move to a distant metastatic lesion and modulate the tumor microenvironment to form a premetastatic niche. Thus, TD‑EVs might be potential biomarkers for tumor development and metastasis. Additionally, EVs are promising candidates for use as cell‑free vaccines or as vehicles for the delivery of specific tumor therapeutic molecules. Genetically modified microvesicles and engineered exosomes have shed light on a novel strategy for tumor‑targeted gene therapy. This review focuses on the role of EVs in tumor development and metastasis and their possible applications in the advanced diagnosis and therapy of cancer and personalized medicine. AD - Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of Xintai, Xintai, Shandong 271200, P.R. China School of Medicine, Soochow University, Suzhou, Jiangsu 215123, P.R. China School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China AU - Qiao,Fuhao AU - Pan,Peng AU - Yan,Jiaping AU - Sun,Jing AU - Zong,Yan AU - Wu,Zhiyong AU - Lu,Xiaoqin AU - Chen,Na AU - Mi,Rui AU - Ma,Yongbin AU - Ji,Yuan DA - 2019/05/01 DO - 10.3892/ijo.2019.4745 EP - 1533 IS - 5 JO - Int J Oncol KW - tumor‑derived microvesicles premetastatic niche biomarkers targeted therapy PY - 2019 SN - 1019-6439 1791-2423 SP - 1525 ST - Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review) T2 - International Journal of Oncology TI - Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review) UR - https://doi.org/10.3892/ijo.2019.4745 VL - 54 ER -