TY - JOUR AB - Recent evidence suggests that numerous long non‑coding RNAs (lncRNAs) are dysregulated in cancer, and have critical roles in tumour development and progression. The present study investigated the ghrelin receptor antisense lncRNA growth hormone secretagogue receptor opposite strand (GHSROS) in breast cancer. Reverse transcription‑quantitative polymerase chain reaction revealed that GHSROS expression was significantly upregulated in breast tumour tissues compared with normal breast tissue. Induced overexpression of GHSROS in the MDA‑MB‑231 breast cancer cell line significantly increased cell migration in vitro, without affecting cell proliferation, a finding similar to our previous study on lung cancer cell lines. Microarray analysis revealed a significant repression of a small cluster of major histocompatibility class II genes and enrichment of immune response pathways; this phenomenon may allow tumour cells to better evade the immune system. Ectopic overexpression of GHSROS in the MDA‑MB‑231 cell line significantly increased orthotopic xenograft growth in mice, suggesting that in vitro culture does not fully capture the function of this lncRNA. This study demonstrated that GHSROS may serve a relevant role in breast cancer. Further studies are warranted to explore the function and therapeutic potential of this lncRNA in breast cancer progression. AD - Ghrelin Research Group, Translational Research Institute-Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland 4102, Australia Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA Australian Prostate Cancer Research Centre-Queensland, Translational Research Institute, Brisbane, Queensland 4102, Australia Centre for Comparative Genomics, Murdoch University & Perron Institute for Neurological and Translational Science, Perth, Western Australia 6150, Australia AU - Thomas,Patrick,B. AU - Seim,Inge AU - Jeffery,Penny,L. AU - Gahete,Manuel,D. AU - Maugham,Michelle AU - Crisp,Gabrielle,J. AU - Stacey,Andrew AU - Shah,Esha,T. AU - Walpole,Carina AU - Whiteside,Eliza,J. AU - Nelson,Colleen,C. AU - Herington,Adrian,C. AU - Luque,Raúl,M. AU - Veedu,Rakesh,N. AU - Chopin,Lisa,K. DA - 2019/12/01 DO - 10.3892/ijo.2019.4891 EP - 1236 IS - 6 JO - Int J Oncol KW - long non-coding RNA ghrelin receptor gene antisense transcript breast cancer cell migration tumour growth PY - 2019 SN - 1019-6439 1791-2423 SP - 1223 ST - The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth T2 - International Journal of Oncology TI - The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth UR - https://doi.org/10.3892/ijo.2019.4891 VL - 55 ER -