TY - JOUR AB - Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High‑grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirmed that the occurrence and development of gliomas are closely associated with the abnormal expression and regulation of genes. Moreover, the number of studies on the association of the expression of non‑coding RNAs [linear RNAs, microRNAs and circular RNAs (circRNAs)] in human cells with glioma has been gradually increasing in recent years. Among those, circRNAs, previously considered to be ‘splicing errors’, have been shown to be highly expressed in eukaryotic cells and regulate the biological behaviour of gliomas. circRNAs are highly abundant and stable, and have become a research hotspot in the field of glioma molecular biology. The aim of the present review was to focus on the research progress regarding the association between circRNA expression and gliomas, and to provide a theoretical basis according to the currently available literature for further exploring this association. The present study may be of value for the early diagnosis, pathological grading, targeted therapy and prognostic evaluation of gliomas. AD - Hebei University, School of Medicine, Baoding, Hebei 071000, P.R. China Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China Hebei University of Chinese Medicine, Faculty of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, Hebei 050091, P.R. China Hebei University of Chinese Medicine, Faculty of Acupuncture‑Moxibustion and Tuina, Shijiazhuang, Hebei 050200, P.R. China Office of Academic Research, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China AU - Zhang,Yuhao AU - Lin,Xiaomeng AU - Geng,Xiuchao AU - Shi,Liang AU - Li,Qiang AU - Liu,Fulin AU - Fang,Chuan AU - Wang,Hong DA - 2020/07/01 DO - 10.3892/ijo.2020.5049 EP - 79 IS - 1 JO - Int J Oncol KW - circular RNAs glioma glioblastoma function mechanism central nervous system biomarker gene therapy correlation research progress PY - 2020 SN - 1019-6439 1791-2423 SP - 67 ST - Advances in circular RNAs and their role in glioma (Review) T2 - International Journal of Oncology TI - Advances in circular RNAs and their role in glioma (Review) UR - https://doi.org/10.3892/ijo.2020.5049 VL - 57 ER -