TY - JOUR AB - Docetaxel, one of the most effective anticancer drugs for gastric cancer, targets β-tubulin, the major protein in mitotic spindles. Eight isotypes of β-tubulin, with tissue and organ-specific expression, have been identified in mammalian cells. We examined class III β-tubulin expression in gastric cancer and assessed its relationship with sensitivity to docetaxel-based chemotherapy. A total of 115 paraffin-embedded gastric tumors were analyzed by immunohistochemistry for class III β-tubulin expression. Twenty patients with advanced gastric cancer received preoperative docetaxel-based chemotherapy. Their biopsied specimens, obtained by endoscopy before chemotherapy were examined for class III β-tubulin expression. The relationship between expression and chemosensitivity was assessed. Forty-two (36.4%) of 115 cases were confirmed to be positive for class III β-tubulin expression. There was no association between clinicopathological status and prognosis. Among the patients positive for class III β-tubulin expression, only 16.7% showed no response to chemotherapy, while 64.3% responded to the chemotherapy in the negative group. Our results suggest that class III β-tubulin is a simple and useful predictive marker for the clinical response to docetaxel-based chemotherapy in gastric cancer. AD - Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan null AU - Urano,Naomi AU - Fujiwara,Yoshiyuki AU - Doki,Yuichiro AU - Kim,S.,J. AU - Miyoshi,Yasuo AU - Noguchi,Shinzaburo AU - Miyata,Hiroshi AU - Takiguchi,Shuji AU - Yasuda,Takushi AU - Yano,Masahiko AU - Monden,Morito DA - 2006/02/01 DO - 10.3892/ijo.28.2.375 EP - 381 IS - 2 JO - Int J Oncol PY - 2006 SN - 1019-6439 1791-2423 SP - 375 ST - Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer T2 - International Journal of Oncology TI - Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer UR - https://doi.org/10.3892/ijo.28.2.375 VL - 28 ER -