TY - JOUR AB - The synthesis of three cationic 5,15-diphenyl porphyrins, bearing an isothiocyanate group for conjugation to proteins is described. The potential of these compounds as targeted photosensitisers for use in photodynamic therapy (PDT) is demonstrated by their efficient conjugation to monoclonal antibodies and the ability of the bioconjugates to bind and photodynamically inactivate cancer cells that express the corresponding antigen. AD - Department of Chemistry and Clinical Biosciences Institute, University of Hull, Kingston-upon-Hull, East Yorkshire, UK null AU - Malatesti,Nela AU - Smith,Karen AU - Savoie,Huguette AU - Greenman,John AU - Boyle,Ross,W. DA - 2006/06/01 DO - 10.3892/ijo.28.6.1561 EP - 1569 IS - 6 JO - Int J Oncol PY - 2006 SN - 1019-6439 1791-2423 SP - 1561 ST - Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers T2 - International Journal of Oncology TI - Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers UR - https://doi.org/10.3892/ijo.28.6.1561 VL - 28 ER -