TY - JOUR AB - Isothiocyanates (ITCs) from cruciferous vegetables have been shown to be effective in blocking initiation as well as progression of a range of chemically-induced tumors in animal models. In this study, sulforaphane, the most extensively studied ITC, was found to suppress the growth of T24 bladder cancer cells in vitro in a dose-dependent manner. Sulforaphane inhibited the proliferation of T24 cells with IC50 values 26.9 and 15.9 µM following 24 and 48 h treatments. Sulforaphane (5-20 µM) induced early apoptosis and blocked cell cycle progression at G0/G1 phase which was associated with upregulation of cyclin-dependent kinase inhibitor p27 expression. These results support a role for sulforaphane as an effective agent in the chemoprevention of bladder cancer. AD - Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150081, P.R. China null AU - Shan,Yujuan AU - Sun,Changhao AU - Zhao,Xiujuan AU - Wu,Kun AU - Cassidy,Aedin AU - Bao,Yongping DA - 2006/10/01 DO - 10.3892/ijo.29.4.883 EP - 888 IS - 4 JO - Int J Oncol PY - 2006 SN - 1019-6439 1791-2423 SP - 883 ST - Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells T2 - International Journal of Oncology TI - Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells UR - https://doi.org/10.3892/ijo.29.4.883 VL - 29 ER -