TY - JOUR AB - The involvement of two tumor suppressors p16 and Ptch in pathogenesis of cutaneous melanomas and basal cell carcinomas (BCCs) was studied through expression of Ptch and p16 and genetic alterations in 9p21 region (p16) and in 9q22.3 region (PTCH) of chromosome 9. Immunohistochemical analyses of paraffin-embedded tissues with Ptch and p16 antibodies, typing for 9q22-q31 and 9p21 region with polymorphic markers and p16 and Ptch mutation detection was done. Higher expression of p16 and Ptch in melanoma and BCC of the skin was frequently detected in studied cases. However, allelic loss of PTCH region occurs more frequently in BCCs than loss of heterozygosity of p16 region. Both types of tumors, BCCs and melanomas, suggest involvement of Hh-Gli signaling pathway, but using different mechanisms. AD - Laboratory for Hereditary Cancer, Division of Molecular Medicine, Rudjer Boskovic Institute, 10002 Zagreb, Croatia null AU - Cretnik,Maja AU - Poje,Gorazd AU - Musani,Vesna AU - Kruslin,Bozo AU - Ozretic,Petar AU - Tomas,Davor AU - Situm,Mirna AU - Levanat,Sonja DA - 2009/04/01 DO - 10.3892/ijo_00000230 EP - 1050 IS - 4 JO - Int J Oncol PY - 2009 SN - 1019-6439 1791-2423 SP - 1045 ST - Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma T2 - International Journal of Oncology TI - Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma UR - https://doi.org/10.3892/ijo_00000230 VL - 34 ER -