TY - JOUR AB - An increased mean platelet volume (MPV) is an early marker of platelet activation. MPV was also shown to be associated with the pathophysiological characteristics of various types of cancer. A previous study demonstrated that MPV was significantly associated with the overall survival (OS) of patients with advanced non-small‑cell lung cancer (NSCLC). However, there has been no analysis of the prognostic effect of MPV on patients with resected NSCLC. The aim of this study was to evaluate the contribution of MPV to the survival of patients with completely resected NSCLC. We retrospectively analyzed 308 consecutive patients with NSCLC who underwent curative resection at Kitano Hospital. The associations between MPV and clinicopathological factors were assessed. We also evaluated the effect of MPV on survival, using the two‑tailed log-rank test and the Cox proportional hazards model. a MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. A low MPV was not associated with any other clinicopathological factors. The two-tailed log-rank test demonstrated that patients with a low MPV experienced a shorter disease-free survival (DFS) and overall survival (OS) (P=0.011 and 0.001, respectively), compared to those with a high MPV. The multivariate analysis demonstrated that a low MPV was an independent unfavorable prognostic factor for DFS and OS [hazard ratio (HR)=1.713; 95% confidence interval (CI): 1.070‑2.742, P=0.025; and HR=2.835; 95% CI: 1.304‑6.163, P=0.009, respectively)]. Therefore, we demonstrated that a low MPV predicted an unfavorable prognosis in patients with NSCLC following curative resection. AD - Respiratory Disease Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka 530-8480, Japan Department of Medical Oncology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka 530-8480, Japan AU - Kumagai,Shogo AU - Tokuno,Junko AU - Ueda,Yuichiro AU - Marumo,Satoshi AU - Shoji,Tsuyoshi AU - Nishimura,Takafumi AU - Fukui,Motonari AU - Huang,Cheng-Long DA - 2015/01/01 DO - 10.3892/mco.2014.436 EP - 201 IS - 1 JO - Mol Clin Oncol KW - lung cancer mean platelet volume overall survival disease-free survival curative resection prognosis PY - 2015 SN - 2049-9450 2049-9469 SP - 197 ST - Prognostic significance of preoperative mean platelet volume in resected non-small‑cell lung cancer T2 - Molecular and Clinical Oncology TI - Prognostic significance of preoperative mean platelet volume in resected non-small‑cell lung cancer UR - https://doi.org/10.3892/mco.2014.436 VL - 3 ER -