TY - JOUR AB - The aim of the present study was to correlate the expression of neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with the invasive capacity of pituitary adenomas. A total of 50 pituitary adenoma tissues and 10 normal pituitary tissues were divided into the invasive group (26 cases), the non‑invasive group (24 cases) and the normal group (10 cases). The expression of NEDD4‑1 and PTEN was determined by immunohistochemistry. NEDD4‑1 was revealed to be located in the nucleus and cytoplasm, whereas PTEN was only located in the cytoplasm. Furthermore, expression of NEDD4‑1 was higher in pituitary adenomas compared with normal pituitary tissues (P<0.05), and higher in the invasive group compared with the non‑invasive group, whereas the opposite trend was observed for PTEN. There was a strong negative correlation between NEDD4‑1 and PTEN expression, indicating a dependency between the two and an association with invasiveness. In conclusion, NEDD4‑1 may serve as a diagnostic and prognostic factor, and as a novel therapeutic target, in pituitary adenomas. AD - Department of Neurosurgery, Heze Municipal Hospital, Heze, Shandong 274000, P.R. China Department of Neurosurgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China AU - Zhang,Jing AU - Li,Xin AU - Zhang,Yanyan DA - 2017/01/01 DO - 10.3892/mco.2016.1092 EP - 100 IS - 1 JO - Mol Clin Oncol KW - invasion neural precursor cells developmentally downregulated 4‑1 phosphatase and tensin homolog deleted on chromosome 10 pituitary adenomas immunohistochemistry PY - 2017 SN - 2049-9450 2049-9469 SP - 96 ST - Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas T2 - Molecular and Clinical Oncology TI - Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas UR - https://doi.org/10.3892/mco.2016.1092 VL - 6 ER -