TY - JOUR AB - Compared with traditional chemotherapy, targeted cancer therapy is a novel strategy in which key molecules in signaling pathways involved in carcinogenesis and tumor spread are inhibited. Targeted cancer therapy has fewer adverse effects on normal cells and is considered to be the future of chemotherapy. However, targeted cancer therapy‑induced cardiovascular toxicities are occasionally critical issues in patients who receive novel anticancer agents, such as trastuzumab, bevacizumab, sunitinib and imatinib. The aim of this review was to discuss these most commonly used drugs and associated incidence of cardiotoxicities, including left ventricular dysfunction, heart failure, hypertension and thromboembolic events, as well as summarize their respective molecular mechanisms of cardiovascular adverse effects. AD - Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China Department of Pathology, Baylor Scott and White Memorial Hospital, Texas A&M Health Science Center, Temple, TX 76508, USA AU - Chen,Zi AU - Ai,Di DA - 2016/05/01 DO - 10.3892/mco.2016.800 EP - 681 IS - 5 JO - Mol Clin Oncol KW - tyrosine kinase inhibitor trastuzumab bevacizumab imatinib sunitinib PY - 2016 SN - 2049-9450 2049-9469 SP - 675 ST - Cardiotoxicity associated with targeted cancer therapies (Review) T2 - Molecular and Clinical Oncology TI - Cardiotoxicity associated with targeted cancer therapies (Review) UR - https://doi.org/10.3892/mco.2016.800 VL - 4 ER -