TY - JOUR AB - The present study was conducted to investigate the protective effect of hydrogen‑rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single‑blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February 2016, among whom 146 met the inclusion criteria. Subsequently, 144 patients were randomized into the treatment (n=80) and placebo (n=64) groups. At the end of the study, 76 patients in the hydrogen treatment group and 60 patients in the placebo group were included in the final analysis. The changes in liver function after the chemotherapy, such as altered levels of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase, indirect bilirubin (IBIL) and direct bilirubin, were observed. The damaging effects of the mFOLFOX6 chemotherapy on liver function were mainly represented by increased ALT, AST and IBIL levels. The hydrogen‑rich water group exhibited no significant differences in liver function before and after treatment, whereas the placebo group exhibited significantly elevated levels of ALT, AST and IBIL. Thus, hydrogen‑rich water appeared to alleviate the mFOLFOX6‑related liver injury. AD - Department of Oncology, Shandong Provincial Taishan Hospital, Taian, Shandong 271000, P.R. China Department of Pathology, Taishan Medical University, Taian, Shandong 271000, P.R. China Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China AU - Yang,Qingxi AU - Ji,Guangdong AU - Pan,Rongtao AU - Zhao,Yinghui AU - Yan,Peng DA - 2017/11/01 DO - 10.3892/mco.2017.1409 EP - 896 IS - 5 JO - Mol Clin Oncol KW - colorectal cancer hydrogen‑rich water chemotherapy mFOLFOX6 liver damage PY - 2017 SN - 2049-9450 2049-9469 SP - 891 ST - Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy T2 - Molecular and Clinical Oncology TI - Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy UR - https://doi.org/10.3892/mco.2017.1409 VL - 7 ER -