TY - JOUR AB - Chemotherapy for lymphoma may be avoided in the presence of coincident cytopenia. In case of immune cytopenia secondary to lymphoma, treatment of cytopenia is the same for primary cases, however, chemotherapy for lymphoma may be effective at the cost of severe hematological toxicity. The present study reports a complex case of thrombocytopenia and direct antiglobulin test‑negative hemolytic anemia, thus mimicking Evans syndrome, secondary to cluster of differentiation 5‑positive B‑cell lymphoma with massive splenomegaly, in a patient suffering from rheumatoid arthritis for two decades. Treatment with prednisolone, high‑dose dexamethasone, eltrombopag and rituximab for cytopenia were not effective. Chemotherapy with bendamustine subsequently resolved the cytopenia, additionally resulting in a complete remission of lymphoma. Thus, bendamustine may have a role in the management of lymphoma complicated with severe cytopenia. AD - Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Tottori 683‑8503, Japan Division of Rehabilitation, Tottori University Hospital, Yonago, Tottori 683‑8504, Japan Department of Hematology, Tottori University Hospital, Yonago, Tottori 683‑8504, Japan AU - Hosoda,Yuzuru AU - Hagino,Hiroshi AU - Hino,Norihiko AU - Motokura,Toru DA - 2017/11/01 DO - 10.3892/mco.2017.1425 EP - 858 IS - 5 JO - Mol Clin Oncol KW - bendamustine Evans syndrome immune thrombocytopenia splenomegaly rheumatoid arthritis PY - 2017 SN - 2049-9450 2049-9469 SP - 855 ST - Efficacy of bendamustine on thrombocytopenia and hemolytic anemia secondary to CD5‑positive B‑cell lymphoma with massive splenomegaly in a patient with rheumatoid arthritis T2 - Molecular and Clinical Oncology TI - Efficacy of bendamustine on thrombocytopenia and hemolytic anemia secondary to CD5‑positive B‑cell lymphoma with massive splenomegaly in a patient with rheumatoid arthritis UR - https://doi.org/10.3892/mco.2017.1425 VL - 7 ER -