TY - JOUR AB - The purpose of the present study was to evaluate the correlation between molecular factors such as BRCA1 DNA repair associated (BRCA1), checkpoint kinase 2 (CHEK2) and nucleotide binding oligomerization domain containing 2 (NOD2) gene mutations and clinicopathological factors in patients with breast cancer (BC). Prognostic factors were analyzed in BC patients with confirmed BRCA1 (n=73), CHEK2 (n=51) and NOD2 (n=31) mutations. The control group was selected from BC patients without mutations (n=392). The BRCA‑associated cancer cases were significantly more often triple negative compared with sporadic cancer (62% vs. 14%; P=0.0001). Luminal B HER2‑positive and HER2‑positive non‑luminal subtypes were observed more often in the control group (33 and 17%). The luminal A subtype was detected in 53% of CHEK2 mutation carriers and 45% of NOD2 mutation carriers. A lower histological grade was observed significantly more often in patients with CHEK2 mutations in comparison with the control group (88 vs. 69%; P=0.003). Lymph nodes without metastases were reported more frequently in NOD2 mutation carriers (74 vs. 54%; P=0.038), in BRCA1 mutations (73 vs. 54%; P=0.004) and, although not significantly, in CHEK2 mutation carriers (69 vs. 54%; P=0.071) compared with the control group. In conclusion, BRCA1 mutation was associated with TNBC and the luminal B HER2 (‑) subtype. HER2‑positive subtypes were characteristic of the control group. CHEK2 and NOD2 mutation carriers had a more favorable profile of prognostic factors. AD - I Radiation and Clinical Oncology Department, Maria Skłodowska‑Curie Memorial Cancer Center and Institute of Oncology, 44‑101 Gliwice, Poland Biostatistic Unit, Maria Skłodowska‑Curie Memorial Cancer Center and Institute of Oncology, 44‑101 Gliwice, Poland AU - Huszno,Joanna AU - Kolosza,Zofia DA - 2019/08/01 DO - 10.3892/mco.2019.1869 EP - 200 IS - 2 JO - Mol Clin Oncol KW - breast cancer BRCA gene mutation CHEK2 gene mutation NOD2 gene mutation clinicopathological factors PY - 2019 SN - 2049-9450 2049-9469 SP - 192 ST - Molecular characteristics of breast cancer according to clinicopathological factors T2 - Molecular and Clinical Oncology TI - Molecular characteristics of breast cancer according to clinicopathological factors UR - https://doi.org/10.3892/mco.2019.1869 VL - 11 ER -