TY - JOUR
AB - Genetic alteration and programmed death‑ligand 1 (PD‑L1) expression have been revealed to be associated with various subtypes of pulmonary adenocarcinoma (ADC). The present study aimed to explore the association between histological subtypes and genetic alterations and PD‑L1 expression. A total of 375 cases of pulmonary ADC were included. Genetic alterations were determined using next generation sequencing (NGS) in 136 cases. PD‑L1 expression was detected by immunohistochemistry (based on clone 22C3) in the remaining 239 cases. Mutations in the epidermal growth factor receptor gene (EGFR) were detected in 76 (55.8%) cases associated with the papillary subtype (P=0.038). Mutations in the Kirsten rat sarcoma viral oncogene homolog gene (KRAS) were present in 46 (33.8%) cases associated with the lepidic subtype (P<0.001) and mucinous ADC (P=0.037). PD‑L1 expression was identified in 63 (26.4%) cases associated with the solid subtype (P<0.001). In conclusion, the present study demonstrated that EGFR and KRAS mutations, alongside PD‑L1 protein expression are significantly associated with specific subtypes of pulmonary ADC. These results should aid our ability to accurately select appropriate areas of the heterogeneous tumor for molecular testing methods and to predict patient outcomes and prognosis.
AD - Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
AU - Phruttinarakorn,Bantita
AU - Reungwetwattana,Thanyanan
AU - Incharoen,Pimpin
DA - 2020/09/01
DO - 10.3892/mco.2020.2082
IS - 3
JO - Mol Clin Oncol
KW - pulmonary adenocarcinoma
programmed death‑ligand 1 expression
subtype
genetic alteration
PY - 2020
SN - 2049-9450
2049-9469
SP - 12
ST - Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma
T2 - Molecular and Clinical Oncology
TI - Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma
UR - https://doi.org/10.3892/mco.2020.2082
VL - 13
ER -