TY - JOUR AB - Central nervous system (CNS) involvement is a rare manifestation of multiple myeloma (MM) and the optimal management strategies have yet to be determined. The aim of the present study was to describe the case of a 47‑year‑old male patient with immunoglobulin D‑λ MM who presented with multiple extramedullary infiltrations at diagnosis. This patient achieved stringent complete response after 9 cycles of treatment with bortezomib, lenalidomide and dexamethasone, and then received lenalidomide as maintenance therapy. CNS involvement and extramedullary relapse developed 3 months after the last chemotherapy cycle. Despite receiving a second‑line treatment protocol, the patient succumbed to the disease within 1 month after recurrence. The characteristics and treatment options for CNS MM are discussed in this case report. AD - Fujian Provincial Key Laboratory on Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fuzhou, Fujian 350001, P.R. China AU - Chen,Yi AU - Qiu,Yanyan AU - Fu,Haiying AU - Li,Jing AU - Chen,Lushan AU - Liao,Siqin AU - Liu,Tingbo DA - 2021/10/01 DO - 10.3892/mco.2021.2360 IS - 4 JO - Mol Clin Oncol KW - multiple myeloma extramedullary central nervous system involvement PY - 2021 SN - 2049-9450 2049-9469 SP - 198 ST - IgD multiple myeloma with central nervous system involvement: A case report and literature review T2 - Molecular and Clinical Oncology TI - IgD multiple myeloma with central nervous system involvement: A case report and literature review UR - https://doi.org/10.3892/mco.2021.2360 VL - 15 ER -