TY - JOUR AB - The most effective treatment for pulmonary metastasis from colorectal cancer (CRC) is complete resection. However, as the recurrence rate after resection of the pulmonary metastases from CRC is high, postoperative adjuvant chemotherapy is often performed in clinical practice. The purpose of the present study was to evaluate the efficacy and safety of single‑agent adjuvant chemotherapy after resection of pulmonary metastasis from CRC. The medical records of 16 patients who underwent the first complete resection of pulmonary metastasis from CRC were retrospectively reviewed. A total of eight patients were treated with single‑agent adjuvant chemotherapy after resection of pulmonary metastasis, and oral fluoropyrimidines were selected in all regimens. As a result, the relapse‑free survival rate after resection of pulmonary metastasis in the group that received postoperative adjuvant chemotherapy was significantly improved in comparison with the group treated with surgery alone. In the subgroup analysis, patients who benefited from postoperative adjuvant chemotherapy in some high‑risk groups were selected, including patients with a high tumor stage or poor immunological status. In conclusion, single‑agent adjuvant chemotherapy after resection of pulmonary metastasis from CRC was effective for reducing the risk of recurrence and was safe to administer. In addition, certain risk factors may identify patients who would receive more benefit from postoperative adjuvant chemotherapy after resection of pulmonary metastasis from CRC. AD - Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno‑ku, Osaka 545‑8585, Japan Department of Gastroenterological Surgery, Osaka City General Hospital, Miyakojima-ku, Osaka 534‑0021, Japan AU - Okazaki,Yuki AU - Shibutani,Masatsune AU - Wang,En AU - Nagahara,Hisashi AU - Fukuoka,Tatsunari AU - Iseki,Yasuhito AU - Maeda,Kiyoshi AU - Hirakawa,Kosei AU - Ohira,Masaichi DA - 2021/10/01 DO - 10.3892/mco.2021.2367 IS - 4 JO - Mol Clin Oncol KW - adjuvant chemotherapy pulmonary metastasis colorectal cancer complete resection fluoropyrimidines PY - 2021 SN - 2049-9450 2049-9469 SP - 205 ST - Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer T2 - Molecular and Clinical Oncology TI - Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer UR - https://doi.org/10.3892/mco.2021.2367 VL - 15 ER -