TY - JOUR AB - There is no consensus in clinical practice on the optimal bladder volume during brachytherapy. The present study aimed to assess the effect of bladder volume on radiation dose to organs at risk and tumor in cervical cancer during image‑guided adaptive brachytherapy and clinical outcome. The retrospective study included patients treated at University of Hong Kong‑Shenzhen Hospital between January 2015 and July 2019. Patients with International Federation of Gynecology and Obstetrics (2009) stage IB1‑IVB (retroperitoneal lymph nodes metastasis only) cervical cancer treated by external beam radiotherapy with concurrent cisplatin followed by brachytherapy were assessed. A total of 421 brachytherapy insertions were analyzed. Every 83 and 90 cm3 (cc) increase in bladder volume led to an incremental raise of 1 Gy in bladder wall minimum dose received by the most irradiated 1 and 2 cc volumes (D1 and D2cc) of the bladder wall, respectively. An increase in bladder volume was associated with increased D1 and D2cc of bladder (both P<0.001, respectively) and rectal wall (P=0.150 and P=0.084, respectively), and decreased D1cc (P=0.003) and D2cc (P=0.001) of sigmoid wall, the maximum doses to the most minimally exposed 90 (D90) and 95% (D95) of the high risk‑clinical target volume (HR‑CTV; D90, P=0.010; D95, P=0.006). Patients with cumulative HR‑CTV D90≤89.6 Gy had shorter median overall survival (OS) than those with cumulative HR‑CTV D90>89.6 Gy (42.1 months vs. not reached, P=0.001). Patients with grade 2 acute urinary toxicity had significantly higher cumulative bladder wall D2cc than those with acute urinary toxicity<grade 2 (86.7±3.7 vs. 78.5±7.9 Gy; P=0.001). As the bladder volume increased, the dose to the bladder and rectal wall increase and dose to the sigmoid colon wall and HR‑CTV decrease based on intracavitary brachytherapy. The higher dose of HR‑CTV predicted better OS and the higher dose received by the bladder wall was associated with more grade 2 acute urinary toxicity. AD - Oncology Medical Center, The University of Hong Kong‑Shenzhen Hospital, Shenzhen, Guangdong 518053, P.R. China Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China AU - Xu,Zhiyuan AU - Yang,Li AU - Ma,Lingyu AU - Liu,Qin AU - Chang,Amy,Ty AU - Zhou,Yong AU - Zhou,Cheng AU - Kong,Feng-Ming AU - Chen,Longhua DA - 2021/12/01 DO - 10.3892/mco.2021.2420 IS - 6 JO - Mol Clin Oncol KW - cervical cancer brachytherapy bladder volume radiotherapy dose overall survival PY - 2021 SN - 2049-9450 2049-9469 SP - 258 ST - Effect of bladder volume on radiation doses to organs at risk and tumor in cervical cancer during image‑guided adaptive brachytherapy and treatment outcome analysis T2 - Molecular and Clinical Oncology TI - Effect of bladder volume on radiation doses to organs at risk and tumor in cervical cancer during image‑guided adaptive brachytherapy and treatment outcome analysis UR - https://doi.org/10.3892/mco.2021.2420 VL - 15 ER -