TY - JOUR AB - Sinonasal small cell carcinoma (SmCC) is a rare type of neoplasm. The current case report describes the case of a 30‑year‑old male patient with stage IV SmCC who underwent concurrent radiotherapy (RT) plus etoposide‑cisplatin treatment. Positron emission tomography (PET)/computed tomography (CT) and fibroscopy examination showed complete remission at 3 months post‑treatment. However, leptomeningeal metastasis (LM) occurred at 9 months. A literature search identified no previous case reports describing LM of SmCC. The patient was treated with concurrent RT plus irinotecan‑gemcitabine. During the sixth cycle of irinotecan‑gemcitabine, the patient required intensive care admission due to severe acute respiratory syndrome‑related coronavirus 2‑associated pneumonia. Following clearance of the pneumonia, LM was assessed using PET/CT and MRI at 3 months, which revealed a complete response to irinotecan‑gemcitabine. In May 2021, the patient succumbed to LM following disease recurrence. The findings of this case report should encourage other authors to publish their treatment outcomes regarding SmCC. More clinical trials are required to achieve better results in terms of patient outcome. AD - Department of Otorhinolaryngology‑Head and Neck Surgery, Hospital Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain Department of Medical Oncology, Hospital Universitario Santa Lucia, Cartagena, 30202 Murcia, Spain Department of Anatomical Pathology, Hospital Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain Department of Anatomic Pathology, Hospital Universitario Santa Lucia, Cartagena, 30202 Murcia, Spain Department of Radiology, Hospital Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain AU - Raposo,Alberto AU - Martínez‑Ortiz,María,José AU - Buendía,Ana AU - Guillén,Elena AU - Bermúdez,Cristina AU - García‑Purriños,Francisco DA - 2022/02/01 DO - 10.3892/mco.2021.2481 IS - 2 JO - Mol Clin Oncol KW - sinonasal small cell carcinoma severe acute respiratory syndrome‑related coronavirus 2‑associated pneumonia leptomeningeal metastasis etoposide‑cisplatin irinotecan‑gemcitabine PY - 2022 SN - 2049-9450 2049-9469 SP - 48 ST - Complete remission of stage IV sinonasal small cell neuroendocrine carcinoma: A case report T2 - Molecular and Clinical Oncology TI - Complete remission of stage IV sinonasal small cell neuroendocrine carcinoma: A case report UR - https://doi.org/10.3892/mco.2021.2481 VL - 16 ER -