TY - JOUR AB - A 60‑year‑old woman presented with a 3‑year history of a slow‑growing, painless mass in their left parotid gland. Ultrasonography revealed a well‑circumscribed, lobulated, hypoechoic mass measuring 19x12x10 mm in the left parotid gland. Computed tomography revealed a well‑circumscribed, solid mass with homogeneous enhancement. Fluorodeoxyglucose‑positron emission tomography revealed uptake by the tumor but no uptake in other organs, including the nasopharynx. The patient underwent superficial parotidectomy with adequate safety margins and selective neck dissection followed by radiotherapy. No facial paralysis or recurrence of the tumor had been observed as of 20 months post‑operation. Histologically, the tumor was composed of sheets of syncytial cancer cells with prominent nucleoli in a dense lymphoplasmacytic background. Epstein‑Barr virus (EBV)‑encoded RNA in situ hybridization was diffusely positive in the tumor cells. These findings indicated that the tumor was an EBV‑associated lymphoepithelial carcinoma. Metastasis, especially from the nasopharynx, was excluded endoscopically and radiologically. Targeted next‑generation sequencing of 160 cancer‑related genes using the surgical specimen revealed no mutations, including known significant mutations detected in EBV‑associated nasopharyngeal carcinoma. AD - Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan Department of Radiation Therapy, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan Department of Pathology and Genetics, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan Keio Cancer Center, Keio University School of Medicine, Tokyo 160-8582, Japan Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71103, USA AU - Kubota,Akinobu AU - Bandoh,Nobuyuki AU - Goto,Takashi AU - Matsumoto,Ken-Ichi AU - Yamaguchi-Ishochi,Tomomi AU - Kato,Yasutaka AU - Nishihara,Hiroshi AU - Takei,Hidehiro DA - 2023/03/01 DO - 10.3892/mco.2023.2620 IS - 3 JO - Mol Clin Oncol KW - lymphoepithelial carcinoma parotid gland Epstein‑Barr virus next generation sequencing PY - 2023 SN - 2049-9450 2049-9469 SP - 24 ST - Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review T2 - Molecular and Clinical Oncology TI - Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review UR - https://doi.org/10.3892/mco.2023.2620 VL - 18 ER -