TY - JOUR AB - Isolated fourth ventricle is a rare complication following shunt insertion of the lateral ventricles for hydrocephalus. The present report describes a rare case of a hemangioblastoma of the medulla oblongata that caused isolated fourth ventricle due to intraventricular deposition of fibrin. A 34‑year‑old man presented with headache a month before admission. Magnetic resonance imaging indicated multiple tumors in the medulla oblongata and the bilateral cerebellar hemisphere with surrounding edema, and the patient was diagnosed with hemangioblastoma. The patient began to develop progressive headache and nausea after stereotactic radiosurgery, and computed tomography showed obstructive hydrocephalus. Endoscopic third ventriculostomy was performed, and the intraoperative view of this showed that the walls of the lateral and third ventricles were covered with a white membrane‑like substance. Endoscopic third ventriculostomy and then ventriculoperitoneal shunt did not improve the hydrocephalus. The patient's consciousness deteriorated due to isolated fourth ventricle and upward herniation. The patient underwent posterior fossa craniotomy and the tumor in the medulla oblongata was removed via a telovelar approach. Intraoperatively, the fourth ventricle was filled with a white membrane‑like substance, which was surgically removed and pathologically diagnosed as fibrin. The patient's consciousness and obstructive hydrocephalus improved after surgery. The present case suggests that isolated fourth ventricle may occur after VP shunt placement for the hydrocephalus with hyperproteinorachia. AD - Department of Neurological Surgery, School of Medicine, Wakayama Medical University, Wakayama, Wakayama 641‑8510, Japan AU - Hama,Yuya AU - Sasaki,Takahiro AU - Yamoto,Toshikazu AU - Fukai,Junya AU - Nishibayashi,Hiroki AU - Nakao,Naoyuki DA - 2023/05/01 DO - 10.3892/mco.2023.2633 IS - 5 JO - Mol Clin Oncol KW - hemangioblastoma hydrocephalus isolated fourth ventricle von Hippel‑Lindau syndrome hyperproteinorachia PY - 2023 SN - 2049-9450 2049-9469 SP - 37 ST - Hemangioblastoma of the medulla oblongata that caused isolated fourth ventricle after stereotactic radiosurgery: A case report T2 - Molecular and Clinical Oncology TI - Hemangioblastoma of the medulla oblongata that caused isolated fourth ventricle after stereotactic radiosurgery: A case report UR - https://doi.org/10.3892/mco.2023.2633 VL - 18 ER -