TY - JOUR AB - The ectocervical epithelium is the target of the oncogenic human papillomavirus (HPV), which acts as an etiological agent in the development of cervical carcinoma. However, the HPV-mediated transformation of human epithelial cells is a multi-step process dependant on unknown factors additional to the virus, which is a necessary but, in and of itself, insufficient catalyst. In the present study, we characterized the role of insulin-like growth factor-I (IGF-I) in this process. IGF-I is an endocrine hormone with an autocrine and paracrine role in many tissues. Our data demonstrated that autocrine secretion of IGF-I can contribute to HPV-induced carcinogenesis of the epithelium. An immunohistochemical study showed that IGF-I was present in the nuclei of the reproductive layer of the paraepidermal epithelium in 89% of cases of intraepithelial neoplasia (CIN I-III) and 60% of cases of invasive cervical cancer. The presence of IGF-I at a nuclear localization in the cells studied suggests that it may also have intranuclear actions. AD - Division of Uterine Cervix Pathophysiology, University of Medical Sciences, 60-535 Poznan, Poland null AU - Jozefiak,Agata AU - Pacholska-Bogalska,Joanna AU - Myga-Nowak,Magdalena AU - Kedzia,Witold AU - Kwasniewska,Anna AU - Luczak,Michal AU - Kedzia,Helena AU - Gozdzicka-Jozefiak,Anna DA - 2008/03/01 DO - 10.3892/mmr.1.2.231 EP - 237 IS - 2 JO - Mol Med Rep PY - 2008 SN - 1791-2997 1791-3004 SP - 231 ST - Serum and tissue levels of insulin-like growth factor-I in women with dysplasia and HPV-positive cervical cancer T2 - Molecular Medicine Reports TI - Serum and tissue levels of insulin-like growth factor-I in women with dysplasia and HPV-positive cervical cancer UR - https://doi.org/10.3892/mmr.1.2.231 VL - 1 ER -