TY - JOUR AB - Vasculogenic mimicry (VM) has increasingly been recognized as a form of angiogenesis. Previous studies have shown that the existence of VM is associated with poor clinical prognosis in certain malignant tumors. However, whether VM is present and clinically significant in intracranial hemangiopericytoma (HPC) is unknown. The present study was therefore designed to examine the expression of VM in intracranial HPC and its correlation with matrix metalloprotease-2 (MMP-2) and vascular endothelial growth factor (VEGF). A total of 17 intracranial HPC samples, along with complete clinical and pathological data, were collected for our study. Immunohistochemistry was performed to stain tissue sections for CD34, periodic acid-Schiff, VEGF and MMP-2. The levels of VEGF and MMP-2 were compared between tumor samples with and without VM. The results showed that VM existed in 12 of 17 (70.6%) intracranial HPC samples. The presence of VM in tumors was associated with tumor recurrence (P<0.05) and expression of MMP-2 (P<0.05). However, there was no difference in the expression of VEGF between groups with and without VM. AD - Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China Department of Neurosurgery, Heze Municipal Hospital, Heze, Shandong 274031, P.R. China Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China ADepartment of Neurosurgery, Provincial Hospital affiliated to Shandong University, Jinan, Shandong 250021, P.R. China AU - Zhang,Zhen AU - Han,Yun AU - Zhang,Keke AU - Teng,Liangzhu DA - 2011/11/01 DO - 10.3892/mmr.2011.567 EP - 1298 IS - 6 JO - Mol Med Rep KW - hemangiopericytoma vasculogenic mimicry matrix metalloproteinase-2 vascular epithelial growth factor PY - 2011 SN - 1791-2997 1791-3004 SP - 1295 ST - Investigation of vasculogenic mimicry in intracranial hemangiopericytoma T2 - Molecular Medicine Reports TI - Investigation of vasculogenic mimicry in intracranial hemangiopericytoma UR - https://doi.org/10.3892/mmr.2011.567 VL - 4 ER -