TY - JOUR AB - P-glycoprotein (P-gp) plays a key role in the distribution and elimination of many clinically important therapeutic substances. P-gp inhibition is capable of increasing the concentration of various drugs in the brain. Danshensu is a main hydrophilic constituent of Salvia miltiorrhiza Bunge which is used traditionally to treat cerebrovascular diseases. In the present study, the effects of cerebral ischemia/reperfusion on the transport of Danshensu in the brain were observed by assaying the concentration at 15, 30 and 60 min after cerebral ischemia/reperfusion in the brain of rats. Furthermore, the expression of P-gp in the brain was also measured. Results showed that Danshensu concentrations in the ischemic hemisphere significantly increased compared to those in the non-ischemic hemisphere and the brain of the sham group. P-gp expression was inhibited by cerebral ischemia/reperfusion to some extent, and down-regulated much more by Danshensu treatment. The findings indicate that the down-regulation of P-gp expression induced by both cerebral ischemia/reperfusion and Danshensu treatment contributes to the increase of Danshensu accumulation in the brain. AD - Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China AU - Chong,Yating AU - Wang,Tian AU - Wang,Wenyan AU - Zhang,Leiming AU - Li,Chong AU - Yu,Pengfei AU - Wang,Hongsheng AU - Fu,Fenghua DA - 2012/03/01 DO - 10.3892/mmr.2011.691 EP - 816 IS - 3 JO - Mol Med Rep KW - Danshensu P-glycoprotein blood-brain barrier cerebral ischemia/reperfusion central nervous system PY - 2012 SN - 1791-2997 1791-3004 SP - 812 ST - Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain T2 - Molecular Medicine Reports TI - Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain UR - https://doi.org/10.3892/mmr.2011.691 VL - 5 ER -