TY - JOUR AB - Recurrence of bladder cancer following transurethral resection of bladder tumor (TURBt) is an obstacle in clinical management. In the current study, we investigated the antitumor activity of baicalein, a Chinese herbal medicine, against T24 bladder cancer cells in vitro. Baicalein inhibited growth and caused G1/S arrest of the cell cycle in the T24 cells. Moreover, baicalein induced apoptosis via loss of mitochondrial transmembrane potential (ΔΨm), release of cytochrome c and activation of caspase-9 and caspase-3. Baicalein inhibited Akt phosphorylation, downregulated Bcl-2 expression and upregulated Bax expression, which in turn increased the ratio of Bax/Bcl-2. Our results demonstrate that baicalein repressed growth inhibition and induced apoptosis via loss of ΔΨm and activation of caspase-9 and caspase-3 in T24 bladder cancer cells, which indicates that baicalein may be an effective agent in the clinical management of bladder cancer. AD - Department of Urology, Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710004, P.R. China Engineering Research Center of Biotherapy and Translational Medicine of Shaanxi Province, Xi'an Jiaotong University, Xi'an 710004, P.R. China Department of Pathology, Shaanxi Provincial People's Hospital, Xi'an 710068, P.R. China AU - Li,Hong-Liang AU - Zhang,Shu AU - Wang,Yuan AU - Liang,Rong-Rui AU - Li,Jun AU - An,Peng AU - Wang,Zi-Ming AU - Yang,Jun AU - Li,Zong-Fang DA - 2013/01/01 DO - 10.3892/mmr.2012.1123 EP - 270 IS - 1 JO - Mol Med Rep KW - baicalein bladder cancer Akt Bcl-2 apoptosis PY - 2013 SN - 1791-2997 1791-3004 SP - 266 ST - Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells T2 - Molecular Medicine Reports TI - Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells UR - https://doi.org/10.3892/mmr.2012.1123 VL - 7 ER -